10. Alaric and Jo’s Red Wedding (6×21 I’ll Wed You in the Golden Summertime)
The Vampire Diaries met Games of Thrones at the end of season six during Alaric and Jo’s red wedding massacre. When Jo’s evil twin, Kai, appeared out of thin air killing her at the alter along with her unborn twins, and leaving Alaric heartbroken. Kai also knocked Elena out with a sleeping curse during the chaos, resulting in Nina Dobrev leaving the show, and Elena’s fate hanging in limbo as we wait to see if she will wake up during the final season.
The Vampire Diaries returns October 21 at 8 p.m. on The CW.